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Benzodiazepines (those metabolized by cyp3a4, including alprazolam and triazolam): serum levels may be increased by erythromycin; somnolence and confusion have been reported. Avoid drinking alcohol, which can increase some of the side effects of tadalafil. In addition, there have been reports of interactions of erythromycin with drugs not thought to be metabolized by cyp3a, including hexobarbital, phenytoin, and valproate.
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